Disease resolution and immunometabolism in severe malaria

11 May 2024
Job Information

Organisation/Company

KU Leuven

Research Field

Medical sciences » Medicine

Researcher Profile

First Stage Researcher (R1)

Country

Belgium

Application Deadline

30 May 2024 - 00:00 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

38 hours/week

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Reference Number

BAP-2024-294

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Despite the availability of highly efficient and rapidly acting antimalarial drugs, the mortality of complicated malaria remains high (~20%). Therefore, we think that failure of disease resolution upon antimalarial treatment may be the cause of mortality in these patients. Since the mechanisms of disease resolution in malaria are not well understood, we intend to study these mechanisms with a recently developed mouse model and with a clinical study in Africa. Our recent lung single cell transcriptomics study (PLoS Pathog. 2024, 20(1):e1011929) revealed interesting targets, and we plan further mechanistic characterization of critical pathways, including the role of immunometabolic pathways and the proteolytic inactivation of inflammatory chemokines.

Requirements

Research Field

Biological sciences

Education Level

Master Degree or equivalent

Languages

ENGLISH

Level

Excellent

Research Field

Biological sciences

Years of Research Experience

None

Additional Information
Benefits

-    A PhD position in a highly dynamic research group within the excellent environment of the renowned Rega Institute at the KU Leuven.
-    Excellent daily guidance and training.
-    Opportunities to participate in international collaborations and national and international conferences.
-    An interdisciplinary environment with access to state-of-the-art technologies and infrastructure.

Eligibility criteria

-    An excellent curriculum with a Master’s degree in biomedical sciences or in biology, biotechnology, bio-engineering, medicine or pharmacy.
-    Highly motivated to study the immunology and metabolism of malaria, a major tropical infectious disease.
-    Eligibility and suitable profile for application for a fellowship (e.g. FWO) is an important asset.
-    Felasa B certificate to work with laboratory animals.
-    Excellent oral and written communication skills in English.
-    Team player, communicative, good practical lab skills, strong analytical mindset, independent and problem-solving attitude.
-    Some expertise in bioinformatics is a plus.

Selection process

Please include in your application your detailed CV, motivation letter and transcript of study results. Please also include the name, affiliation and e-mail address of two references, as well as their relation to you (e.g. your Msc thesis supervisor or promotor). Please also include a 1-page summary of your MSc thesis.
For more information please contact Prof. dr. Philippe Van den Steen, tel.: +32 16 32 22 87, mail: [email protected] .
You can apply for this job no later than 30/05/2024 via the online application tool

Work Location(s)

Number of offers available

1

Company/Institute

KU Leuven

Country

Belgium

State/Province

Vlaams Brabant

City

Leuven

Postal Code

3000

Street

Leuven

Geofield

Where to apply

Website

https://easyapply.jobs/r/eliVRae21TdUAeWp6DF

Contact

State/Province

Leuven

City

Vlaams Brabant

Street

Leuven

Postal Code

3000

E-Mail

[email protected]

STATUS: EXPIRED