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on computational genomics in application to human disease using registries and biobanks including All of Us Research Program, Million Veterans Program, and UK Biobank, either a single biobank or cross-biobanks using
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utilize humanized organs and humanized mice harboring a human immune system to elucidate the intricate mechanisms underlying chronic inflammation and fibrosis. Through a combination of in vitro and in vivo
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evaluation in state-of-the-art humanized mouse models, which enable studies in the context of a human immune system. The experimental approaches will span molecular biology, immunology, and virology
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of Medicine. The successful candidate will be driving research into the mechanistic biochemical and physiological aspects of how ribosomes are made in eukaryotic cells using model systems ranging from human
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. The candidate will lead a transformational project designed to unravel novel mechanisms of Parkinson’s and to rapidly repurpose therapeutics using human iPSC models. Candidate therapeutics will undergo pre
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to biological questions is also beneficial. Studies incorporate approaches in both primary human immune cells and in vivo mouse intestinal model systems. Education and experience: Candidates must have a PhD or
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al, Nature Biotechnology, 2022) and hifiasm (UL) (Cheng et al, Nature Methods, 2024). These algorithms have been widely used by numerous large-scale sequencing projects, such as the Human Pangenome
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invites applications for a postdoctoral position. The successful candidate will be driving cutting-edge research into the mechanisms and engineering of cell-cell fusion and receptor signaling in human
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over time? How can we develop technology that can process language effectively? By studying such topics, we can use language as a window into the human mind and human society. Overview of the Position
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, Department of Genetics, Yale School of Medicine, the Lake Lab. Our lab uses computational and experimental methods to determine how genetic variation in mitochondria underlie health and disease in humans. We