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Conway Institute of Biomolecular & Biomedical Research | Dublin Bar, Leinster | Ireland | about 1 month ago
institutions world-wide. The project aims to develop three-dimensional in vitro drug discovery pathophysiology models using appropriate human cells (e.g. diabetic, fibrosis, cancer, etc.). State-of-the-art
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non-small-cell lung cancer (NSCLC) patients. NSCLC is the most common type of lung cancer and a deadly disease. Despite new and more effective drugs have been approved in the last years
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to harness this with non-bile acid ligands in drug design for degenerative disorders where dysregulated cell death contributes to disease progression. The project will investigate the potential
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novel RNA-therapeutics. Working collaboratively, they will engineer and evolve transfer RNAs (tRNAs) to decode PTCs within the mRNA of disease related genes and identify strategies to improve delivery
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screening assays to accelerate drug discovery. Project: Building on recent radical protein trapping methodologies developed within the laboratory, this project will involve synthesis and testing a panel of