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/17939/zijie-sun/ ) to investigate the roles of stem cells and stem cell niches in prostate development and tumorigenesis using “cutting-edge” in vivo models and advanced experimental approaches and
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how neural signals are propagated in the bone marrow niche and the consequences of SNS dysfunction on niche aging and the development of myeloid malignancies. The lab specializes in generating complex
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and stem cell niches in prostate development and tumorigenesis using “cutting-edge” and unbiased analytic tools and unique and innovative genetically engineered mouse models (please see some of the
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-22733-9 ). We are interested in conducting structural, mechanistic studies and development of a novel class of inhibitors to disrupt IN-INI1/SMARCB1 interactions based on these studies. Additional
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into these proteins, we aim to decipher the molecular causes of neurodegenerative and neurodevelopmental diseases. By combining single-molecule assays with mutagenesis and cryoEM, the Gennerich lab will develop novel