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cascades of non-genetic alterations is also a black box. We are excited to welcome a PhD candidate to attack these questions. We will combine cutting edge techniques, such as genome engineering and single
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development into Lupus disease OR protection from developing Lupus. Methods will include cell culture including with patient derived skin and blood cells, flow cytometry including with skin and blood derived
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as well as the T cell activation status of specialized DC subsets will be assessed using photoconvertible transgenic mouse models and in vitro co-culture assays. To mimic the clinical manifestations
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in this way will later on be tested in the complex environment of the cell to investigate the effect of condensation on gene expression more directly. Here, mammalian tissue culture will be utilized