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to verify loss-of function phenotypes, gene expression profiling, bacterial survival assays and possibly in vivo experiments in mouse models. Complementary, you will perform antibody profiling studies for GAS
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molecule drugs or therapeutic antibodies, their potential is growing fast. The development and application of Therapeutic Nucleic Acids, in a general, have been drawing the interest of several biotech
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, the diabetes type II related human islet amyloid polypeptide (hIAPP), light chain antibody domains involved in AL-amyloidosis and serum amyloid A (SAA) involved in AA-amyloidosis. We employ solution- and MAS
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membrane-based filtration and chromatography processes. Design separation processes for selected antibodies and small particles. Apply and optimize ultrafiltration to reach final concentration goals. Perform
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. Having seen how new classes of drugs impacted greatly on patients, such as tyrosine kinase inhibitors and chronic myeloid leukaemia, anti-tumour necrosis factor monoclonal antibodies and rheumatology
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create new knowledge on how humoral (antibody-mediated) immunity affects nanomaterials using cutting-edge immunoassays, bio–nano characterisation techniques, and bioinformatics. Expected outcomes
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-supervised by Dr. David Yu (antibodies and PEG) and Dr. Jennifer Boer (bioinformatics analysis). The Cancer, Ageing and Vaccines Laboratory is currently working to better understand the effects and long-term
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PhD Scholarship in ‘Using nanoparticles to enhance the immune response and improve vaccine efficacy’
to the vaccine, particularly regarding inducing a T cell response. Our lab focuses on viral sized nanoparticles as adjuvanting vaccine delivery systems to improve both the antibody mediated and cellular immune