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targets for therapeutic intervention. To do this you will use laboratory-grown, tissue engineered skin that closely mimics the structure and function of human skin. You will make and then use skin cells
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elucidate the mechanisms by which vascular endothelial PKD1 regulates aneurysm development in ADPKD patients. To this aim, they will use in vitro (primary human endothelial cells) and ex vivo approaches
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the absence of telomerase, and how these correlate with gut repair capacity, using zebrafish and human samples. This is a multidisciplinary project, with state-of-the-art methodology, from advanced microscopy
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, vegetable and seed crops for human consumption: over 65% of the top world crops are at least moderately dependent on animal pollinators. Pollination is also crucial for sustaining healthy, genetically diverse
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Details Many human interactions with objects and surfaces rely on perception of the tactile interface. This could be when gripping objects with hands, or controlling walking movements through the physical
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in pose understanding and transfer and interactive editing, enhancing the analysis, creation and manipulation of human/animations in digital media. Character animation, the art of bringing virtual
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. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nat Med 24, 313-325 (2018). 18. Nam, S. E. et al. Insights on autophagosome-lysosome tethering from structural and
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to their environmental inputs. It is now recognised that defective axonal transport is an early pathogenic event that precedes synaptic dysfunction in many human neurodegenerative disorders, including Alzheimer’s disease
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the majority of human disease conditions, especially those with an inflammatory component, including cancer, neurodegeneration, atherosclerosis and chronic inflammatory conditions such as COPD. Furthermore, as
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used in phones and tablet devices). It will focus on imaging techniques and experimental methods to measure biomechanical properties of the hand and link these characteristics with the ability of human